Article
Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group.
Blood - 4 Feb 2010
Hertzberg Libi, Vendramini Elena, Ganmore Ithamar, Cazzaniga Gianni, Schmitz Maike, Chalker Jane, Shiloh Ruth, Iacobucci Ilaria, Shochat Chen, Zeligson Sharon, Cario Gunnar, Stanulla Martin, Strehl Sabine, Russell Lisa J, Harrison Christine J, Bornhauser Beat, Yoda Akinori, Rechavi Gideon, Bercovich Dani, Borkhardt Arndt, Kempski Helena, te Kronnie Geertruy, Bourquin Jean-Pierre, Domany Eytan, Izraeli Shai
Abstract excerpt
We report gene expression and other analyses to elucidate the molecular characteristics of acute lymphoblastic leukemia (ALL) in children with Down syndrome (DS). We find that by gene expression DS-ALL is a highly heterogeneous disease not definable as a unique entity. Nevertheless, 62% (33/53) of the DS-ALL samples analyzed were characterized by high expression of the type I cytokine receptor CRLF2 caused by...
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