Article

Fetal Liver-Restricted Leukemic Proliferation Via GATA1s-CSF2RB-MPL Axis In Down Syndrome

2025-10-21

Abstract excerpt

<title>Abstract</title> <p>Some childhood cancers can arise in utero and then regress at birth, but the cues that permit malignant proliferation in utero as opposed to postnatal life are often unclear. Transient abnormal myelopoiesis (TAM) is a human fetal liver leukemia driven by GATA1s mutations and a rare exemplar of a spontaneously resolving cancer when blood formation shifts from liver to bone marrow (BM) du...

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Literature Corpus work: dac09093-a714-5376-a21c-822b3a7a912a
DOI: 10.21203/rs.3.rs-7842540/v1

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