Article

Novel Anti-virulence Compounds Disrupt Exotoxin Expression in MRSA

2024-05-15

Abstract excerpt

Hemolysins are lytic exotoxins expressed in most strains of S. aureus , but hemolytic activity varies between strains. We have previously reported several novel anti-virulence compounds that disrupt the S. aureus transcriptome, including hemolysin gene expression. This report delves further into our two lead compounds, loratadine and a structurally related brominated carbazole, and their effects on hemolysin pro...

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Literature Corpus work: 585af424-dea7-5d44-8f6f-92170110cea1
DOI: 10.1101/2024.05.15.594412

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