Article
A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence.
eLife - 8 Jun 2023
Hachani Abderrahman, Giulieri Stefano G, Guérillot Romain, Walsh Calum J, Herisse Marion, Soe Ye Mon, Baines Sarah L, Thomas David R, Cheung Shane Doris, Hayes Ashleigh S, Cho Ellie, Newton Hayley J, Pidot Sacha, Massey Ruth C, Howden Benjamin P, Stinear Timothy P
Abstract excerpt
Staphylococcus aureus infections are associated with high mortality rates. Often considered an extracellular pathogen, S. aureus can persist and replicate within host cells, evading immune responses, and causing host cell death. Classical methods for assessing S. aureus cytotoxicity are limited by testing culture supernatants and endpoint measurements that do not capture the phenotypic diversity of intracellular...
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