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Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus

22 Dec 2016

Abstract excerpt

Staphylococcus aureus is a serious human pathogen and antibiotic resistant, community-associated strains, such as the methicillin resistant S. aureus (MRSA) strain USA300, continue to spread. To avoid resistance, anti-virulence therapy has been proposed where toxicity is targeted rather than viability. Previously we have shown that norlichexanthone, a small non-reduced tricyclic polyketide produced by fungi and...

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PMID: 28005941
DOI: 10.1371/journal.pone.0168305

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