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Article

Diversity and evolution of leukotoxin operons in Staphylococcus aureus.

mSystems - 19 May 2026

Souza Stephanie S R, Berlus Marven J, Andam Cheryl P

Abstract excerpt

Staphylococcus aureus is a globally significant and opportunistic pathogen equipped with a diverse arsenal of virulence factors, including bi-component leukotoxins that play a central role in immune evasion and tissue damage. Despite extensive functional characterization of individual leukotoxins, their diversity, phylogenetic distribution, and evolution remain underexplored. Here, we analyzed 1,779 complete S....

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Evolution, Molecular
Exotoxins
Genetic Variation
Genome, Bacterial
Operon
Phylogeny

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Staphylococcus aureus

Virulence Factors

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Identifiers

PMID: 42003605
DOI: 10.1128/msystems.01735-25
PMCID: PMC13185589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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