Article
Natural mutations in a Staphylococcus aureus virulence regulator attenuate cytotoxicity but permit bacteremia and abscess formation.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2016
Das Sudip, Lindemann Claudia, Young Bernadette C, Muller Julius, Österreich Babett, Ternette Nicola, Winkler Ann-Cathrin, Paprotka Kerstin, Reinhardt Richard, Förstner Konrad U, Allen Elizabeth, Flaxman Amy, Yamaguchi Yuko, Rollier Christine S, van Diemen Pauline, Blättner Sebastian, Remmele Christian W, Selle Martina, Dittrich Marcus, Müller Tobias, Vogel Jörg, Ohlsen Knut, Crook Derrick W, Massey Ruth, Wilson Daniel J, Rudel Thomas, Wyllie David H, Fraunholz Martin J
Abstract excerpt
Staphylococcus aureus is a major bacterial pathogen, which causes severe blood and tissue infections that frequently emerge by autoinfection with asymptomatically carried nose and skin populations. However, recent studies report that bloodstream isolates differ systematically from those found in the nose and skin, exhibiting reduced toxicity toward leukocytes. In two patients, an attenuated toxicity bloodstream...
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