Article

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

2023-06-22

Abstract excerpt

Hyperactivity of cardiac sarcoplasmic reticulum (SR) ryanodine receptor (RyR2) Ca 2+ -release channels contributes to heart failure and arrhythmias. Reducing RyR2 activity, particularly during cardiac relaxation (diastole), is a desirable therapeutic goal. We previously reported that the unnatural enantiomer ( ent ) of an insect-RyR activator, verticilide, inhibits porcine and mouse RyR2 at diastolic (nanomolar)...

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Literature Corpus work: 4ee68f41-421a-5dff-b7be-b5e5cc9be925
DOI: 10.1101/2023.06.22.546083

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