Article

Deciphering conformational selectivity in the A <sub>2A</sub> adenosine G protein-coupled receptor by Free Energy simulations

2021-06-09

Abstract excerpt

Transmembranal G Protein-Coupled Receptors (GPCRs) transduce extracellular chemical signals to the cell, via conformational change from a resting (inactive) to an active (canonically bound to a G-protein) conformation. Receptor activation is normally modulated by extracellular ligand binding, but mutations in the receptor can also shift this equilibrium by stabilizing different conformational states. In this work,...

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Literature Corpus work: 1a555ad5-770b-5a3e-8be5-ba9e25661897
DOI: 10.1101/2021.06.09.447724

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