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Article

Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a mutation in adenylyl cyclase with trade-offs for pathogenicity.

Current biology : CB - 9 Oct 2023

Hilbert Zoë A, Bednarek Joseph M, Schwiesow Mara J W, Chung Krystal Y, Moreau Christian T, Brown Jessica C S, Elde Nels C

Abstract excerpt

Pathogenic fungi populate a wide range of environments and infect a diversity of host species. Despite this substantial biological flexibility, the impact of interactions between fungi and their hosts on the evolution of pathogenicity remains unclear. We studied how repeated interactions between the fungus Cryptococcus neoformans and relevant environmental and mammalian host cells-amoeba and mouse...

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Identifiers

PMID: 37708888
DOI: 10.1016/j.cub.2023.08.054
PMCID: PMC10592076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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