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A mutagenesis study of autoantigen optimization for potential T1D vaccine design

11 Apr 2023

Abstract excerpt

A previously reported autoreactive antigen, termed the X-idiotype, isolated from a unique cell population in Type 1 diabetes (T1D) patients, was found to stimulate their CD4+ T cells. This antigen was previously determined to bind more favorably than insulin and its mimic (insulin superagonist) to HLA-DQ8, supporting its strong role in CD4+ T cell activation. In this work, we probed HLA-X-idiotype-TCR binding and...

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PMID: 37040399
DOI: 10.1073/pnas.2214430120

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