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Understanding Cancer’s Defense against Topoisomerase-Active Drugs: A Comprehensive Review

6 Feb 2024

Abstract excerpt

In recent years, the emergence of cancer drug resistance has been one of the crucial tumor hallmarks that are supported by the level of genetic heterogeneity and complexities at cellular levels. Oxidative stress, immune evasion, metabolic reprogramming, overexpression of ABC transporters, and stemness are among the several key contributing molecular and cellular response mechanisms. Topo-active drugs, e.g.,...

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PMID: 38398072
DOI: 10.3390/cancers16040680

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