Article
DNA topoisomerase II, genotoxicity, and cancer.
Mutation research - 1 Oct 2007
McClendon A Kathleen, Osheroff Neil
Abstract excerpt
Type II topoisomerases are ubiquitous enzymes that play essential roles in a number of fundamental DNA processes. They regulate DNA under- and overwinding, and resolve knots and tangles in the genetic material by passing an intact double helix through a transient double-stranded break that they generate in a separate segment of DNA. Because type II topoisomerases generate DNA strand breaks as a requisite...
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