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DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

1 May 2010

Abstract excerpt

DNA topoisomerases are the targets of important anticancer and antibacterial drugs. Camptothecins and novel noncamptothecins in clinical development (indenoisoquinolines and ARC-111) target eukaryotic type IB topoisomerases (Top1), whereas human type IIA topoisomerases (Top2alpha and Top2beta) are the targets of the widely used anticancer agents etoposide, anthracyclines (doxorubicin, daunorubicin), and...

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PMID: 20534341
DOI: 10.1016/j.chembiol.2010.04.012

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