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Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules

6 May 2015

Abstract excerpt

The TOP2 poison etoposide has been implicated in the generation of secondary malignancies during cancer treatment. Structural similarities between TOP2 isoforms challenge the rational design of isoform-specific poisons to further delineate these processes. Herein, we describe the synthesis and biological evaluation of a focused library of etoposide analogues, with the identification of two novel small molecules...

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PMID: 25945730
DOI: 10.1021/acs.jmedchem.5b00473

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