Article

Targeted Long-Read Bisulfite Sequencing for Promoter Methylation Analysis in Severe Preterm Birth

2024-03-08

Abstract excerpt

DNA methylation plays a critical role in the dynamics of gene expression regulation and the development of various disorders. Whole-genome bisulfite sequencing can provide single base resolution of CpG methylation levels and is the “gold standard” for DNA methylation quantification, but it also has a high cost. In contrast, targeted sequencing is optimal when focusing on specific candidate regions, while providing...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 57ea5184-e04a-5a3c-b9fc-fe7a4592fe9a
DOI: 10.1101/2024.03.04.583424

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeted Long-Read Bisulfite Sequencing for Promoter Methylation Analysis in Severe Preterm BirthDOI 10.1101/2024.03.04.583424Read

DNA Methylation in the Fields of Prenatal Diagnosis and Early Detection of CancersSemantic proximity Read

Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing.Semantic proximity Read

Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonatesSemantic proximity Read

SMAP: a streamlined methylation analysis pipeline for bisulfite sequencing.Semantic proximity Read

Comparing methylation levels assayed in GC-rich regions with current and emerging methodsSemantic proximity Read

High-throughput methylome analysis reveals differential methylation for early and late onset preeclampsia for mothers and their childrenSemantic proximity Read

A pooling-based approach to mapping genetic variants associated with DNA methylation.Semantic proximity Read

Genome-wide hypermethylation coupled with promoter hypomethylation in the chorioamniotic membranes of early onset pre-eclampsiaSemantic proximity Read

Genome-wide DNA methylation associations with spontaneous preterm birth in US blacks: findings in maternal and cord blood samplesSemantic proximity Read

Genome-wide oxidative bisulfite sequencing identifies sex-specific methylation differences in the human placentaSemantic proximity Read

An allele-resolved nanopore-guided tour of the human placental methylomeSemantic proximity Read

HAM-TBS: High accuracy methylation measurements via targeted bisulfite sequencingSemantic proximity Read