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Article

High-throughput methylome analysis reveals differential methylation for early and late onset preeclampsia for mothers and their children

8 Jan 2024

Abstract excerpt

Preeclampsia is a life-threatening hypertensive disorder, affecting 2%-5% of pregnancies, that remains poorly understood. This study analyzed DNA methylation from buccal swabs from mothers who experienced early and late-stage preeclampsia and those with uncomplicated pregnancies, along with their children. Differentially methylated regions were found near and within genes crucial for placental function, embryonic...

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PMID: 38189116
DOI: 10.1152/physiolgenomics.00058.2023

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