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Article

CaMKIIα hub ligands are unable to reverse known phenotypes in Angelman syndrome mice.

Basic & clinical pharmacology & toxicology - 1 Jan 2025

Gauger Stine J, Lie Maria E K, Wallaard Ilse, Tian Yongsong, Marek Aleš, Frølund Bente, van Woerden Geeske M, Elgersma Ype, Kornum Birgitte R, Wellendorph Petrine

Abstract excerpt

Angelman Syndrome (AS) is a neurodevelopmental disorder caused by the loss of function of ubiquitin-protein ligase E3A (UBE3A), resulting in marked changes in synaptic plasticity. In AS mice, a dysregulation of Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) was previously described. This has been convincingly validated through genetic rescue of prominent phenotypes in mouse cross-breeding...

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PMID: 39668309
DOI: 10.1111/bcpt.14112

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