Article

Inferring disease architecture and predictive ability with LDpred2-auto

2022-10-12

Abstract excerpt

LDpred2 is a widely used Bayesian method for building polygenic scores (PGS). LDpred2-auto can infer the two parameters from the LDpred model, the SNP heritability h 2 and polygenicity p , so that it does not require an additional validation dataset to choose best-performing parameters. The main aim of this paper is to properly validate the use of LDpred2-auto for inferring multiple genetic parameters. Here, we...

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Literature Corpus work: 579c28d4-60d9-5e92-bef8-968bd236c645
DOI: 10.1101/2022.10.10.511629

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