Article

LDpred2: better, faster, stronger

2020-04-29

Abstract excerpt

Polygenic scores have become a central tool in human genetics research. LDpred is a popular method for deriving polygenic scores based on summary statistics and a matrix of correlation between genetic variants. However, LDpred has limitations that may reduce its predictive performance. Here we present LDpred2, a new version of LDpred that addresses these issues. We also provide two new options in LDpred2: a “spars...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d0f82b3-1c36-595b-b6af-1225c9d05916
DOI: 10.1101/2020.04.28.066720

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LDpred2: better, faster, strongerDOI 10.1101/2020.04.28.066720Read

Inferring disease architecture and predictive ability with LDpred2-auto.Semantic proximity Read

Inferring disease architecture and predictive ability with LDpred2-autoSemantic proximity Read

Incorporating functional priors improves polygenic prediction accuracy in UK Biobank and 23andMe data sets.Semantic proximity Read

RápidoPGS: a rapid polygenic score calculator for summary GWAS data without a test dataset.Semantic proximity Read

Leveraging functional genomic annotations and genome coverage to improve polygenic prediction of complex traits within and between ancestries.Semantic proximity Read

A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score (PRS) Release.Semantic proximity Read

A comprehensive investigation of statistical and machine learning approaches for predicting complex human diseases on genomic variants.Semantic proximity Read

Improving on polygenic scores across complex traits using select and shrink with summary statistics (S4) and LDpred2.Semantic proximity Read

PGS-Depot: a comprehensive resource for polygenic scores constructed by summary statistics based methods.Semantic proximity Read

Constructing a Literature-Derived Database for Benchmarking Polygenic Risk Score Construction Methods with Spectral Ranking InferencesSemantic proximity Read

Genetic prediction of complex traits with polygenic scores: a statistical review.Semantic proximity Read

Resource profile and user guide of the Polygenic Index Repository.Semantic proximity Read