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Article

Inferring disease architecture and predictive ability with LDpred2-auto.

American journal of human genetics - 7 Dec 2023

Privé Florian, Albiñana Clara, Arbel Julyan, Pasaniuc Bogdan, Vilhjálmsson Bjarni J

Abstract excerpt

LDpred2 is a widely used Bayesian method for building polygenic scores (PGSs). LDpred2-auto can infer the two parameters from the LDpred model, the SNP heritability h2 and polygenicity p, so that it does not require an additional validation dataset to choose best-performing parameters. The main aim of this paper is to properly validate the use of LDpred2-auto for inferring multiple genetic parameters. Here, we...

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Identifiers

PMID: 37944514
DOI: 10.1016/j.ajhg.2023.10.010
PMCID: PMC10716363

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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