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Huwe1 Regulates the Establishment and Maintenance of Spermatogonia by Suppressing DNA Damage Response

25 Aug 2017

Abstract excerpt

Spermatogenesis is sustained by a heterogeneous population of spermatogonia that includes the spermatogonial stem cells. However, the mechanisms underlying their establishment from gonocyte embryonic precursors and their maintenance thereafter remain largely unknown. In this study, we report that inactivation of the ubiquitin ligase Huwe1 in male germ cells in mice led to the degeneration of spermatogonia in...

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PMID: 28938460
DOI: 10.1210/en.2017-00396

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