Article

Functional proteomics identifies targetable cancer-associated fibroblast programs in head and neck cancer

2026-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Head and neck squamous cell carcinoma (HNSCC) remains clinically challenging, with limited molecularly targeted options and a strong dependence on the tumor microenvironment. Cancer-associated fibroblasts (CAFs) are major stromal regulators that shape tumor progression, extracellular matrix remodeling, invasion, and therapeutic response. However, how CAF heterogeneity and plasticity translate in...

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Literature Corpus work: 577563ea-c5fe-5fc4-95aa-d2dacc643458
DOI: 10.64898/2026.08.18.745234

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