Article

A Patient-Derived Scaffold-Based 3D Culture Platform for Head and Neck Cancer: Preserving Tumor Heterogeneity for Personalized Drug Testing

2025-08-02

Abstract excerpt

Standard 3-D models for head-and-neck cancer (HNC) often lose stromal partners that influence drug response or never include them. We developed a patient-derived cell culture system that maintains tumor cells, cancer-associated fibroblasts (CAFs), and cells undergoing partial epithelial-to-mesenchymal transition (pEMT) for rapid sensitivity testing. Biopsies from four HNC patients were enzymatically dissociated. C...

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Literature Corpus work: aebf37d0-c47c-509f-b34b-9c50882e0585
DOI: 10.1101/2025.07.31.667921

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