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Multiparameter imaging reveals clinically relevant cancer cell-stroma interaction dynamics in head and neck cancer.

Cell - 12 Dec 2024

Punovuori Karolina, Bertillot Fabien, Miroshnikova Yekaterina A, Binner Mirjam I, Myllymäki Satu-Marja, Follain Gautier, Kruse Kai, Routila Johannes, Huusko Teemu, Pellinen Teijo, Hagström Jaana, Kedei Noemi, Ventelä Sami, Mäkitie Antti, Ivaska Johanna, Wickström Sara A

Abstract excerpt

Epithelial tumors are characterized by abundant inter- and intra-tumor heterogeneity, which complicates diagnostics and treatment. The contribution of cancer-stroma interactions to this heterogeneity is poorly understood. Here, we report a paradigm to quantify phenotypic diversity in head and neck squamous cell carcinoma (HNSCC) with single-cell resolution. By combining cell-state markers with morphological...

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Identifiers

PMID: 39471809
DOI: 10.1016/j.cell.2024.09.046

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