Article

Modeling Down syndrome neurodevelopment with isogenic cerebral organoids

2022-05-26

Abstract excerpt

As a model of early fetal brain development in Down syndrome, this study examines cortical organoids generated from isogenic trisomic and disomic iPSC lines. Initially pools of organoids from a trisomic versus disomic line found broad transcriptomic differences and modest differences in cell-type representation, suggesting a potential neurodevelopmental phenotype due to Trisomy 21. To better control for multiple s...

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Literature Corpus work: d1b03a82-b5bd-5424-b934-8675555bfbe1
DOI: 10.1101/2022.05.25.493459

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