Article

Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer’s Disease phenotypes associated with Down Syndrome

2025-07-30

Abstract excerpt

<h4>ABSTRACT</h4> Down Syndrome (DS) is the most abundant genetic form of mental retardation. It is caused by the triplication of partial or complete human chromosome 21 (HSA21). The molecular mechanisms causing it are not fully understood. Previous studies identified “Down syndrome Critical Region” (DSCR) genes that are essential or sufficient for the development of DS. However, these studies are largely inconcl...

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Literature Corpus work: e0393b21-353d-5fea-af32-553391ff7b3b
DOI: 10.1101/2025.07.30.667706

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