Article

A single DNA methylation site regulates cell fate during <i>Clostridioides difficile</i> sporulation

2025-12-25

Abstract excerpt

DNA methylation is a widespread phenomenon in bacteria that can regulate gene expression, although the mechanisms underlying this epigenetic regulation are often poorly understood. In Clostridioides difficile , the orphan DNA methyltransferase CamA promotes sporulation, a process critical for the persistence and transmission of this nosocomial pathogen. However, the specific CamA target genes that drive this incr...

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Literature Corpus work: 575ad78d-354a-5893-bcf5-5698ea8dc05e
DOI: 10.64898/2025.12.24.696351

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