Article

Role of DNA Methylation in Persister Formation in Uropathogenic <i>E. coli</i>

2020-01-08

Abstract excerpt

Uropathogenic Escherichia coli (UPEC) persister bacteria play crucial roles in clinical treatment failure and relapse. DNA methylation is known to regulate gene expression in bacteria, but its role in persister formation has not been investigated. Here, we created adenine methylation deletion mutant ( Δdam ) and cytosine methylation mutant ( Δdcm ) from UPEC strain UTI89 and found that the Δdam mutant but not...

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Literature Corpus work: 0965c7a2-7084-5372-89ed-b0a74fc0eec8
DOI: 10.1101/2020.01.07.897686

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