Article
Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis.
Nature microbiology - 1 Jan 2020
Oliveira Pedro H, Ribis John W, Garrett Elizabeth M, Trzilova Dominika, Kim Alex, Sekulovic Ognjen, Mead Edward A, Pak Theodore, Zhu Shijia, Deikus Gintaras, Touchon Marie, Lewis-Sandari Martha, Beckford Colleen, Zeitouni Nathalie E, Altman Deena R, Webster Elizabeth, Oussenko Irina, Bunyavanich Supinda, Aggarwal Aneel K, Bashir Ali, Patel Gopi, Wallach Frances, Hamula Camille, Huprikar Shirish, Schadt Eric E, Sebra Robert, van Bakel Harm, Kasarskis Andrew, Tamayo Rita, Shen Aimee, Fang Gang
Abstract excerpt
Clostridioides (formerly Clostridium) difficile is a leading cause of healthcare-associated infections. Although considerable progress has been made in the understanding of its genome, the epigenome of C. difficile and its functional impact has not been systematically explored. Here, we perform a comprehensive DNA methylome analysis of C. difficile using 36 human isolates and observe a high level of epigenomic...
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