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Loss of claudin-3 expression increases colitis risk by promoting Gut Dysbiosis

27 Nov 2023

Abstract excerpt

Dysregulation of both the gut barrier and microbiota (dysbiosis) promotes susceptibility to and severity of Inflammatory Bowel Diseases (IBD). Leaky gut and dysbiosis often coexist; however, potential interdependence and molecular regulation are not well understood. Robust expression of claudin-3 (CLDN3) characterizes the gut epithelium, and studies have demonstrated a positive association between CLDN3...

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PMID: 38010872
DOI: 10.1080/19490976.2023.2282789

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