Article

Secreted Protein Combination GAPDH/S100A8/S100A9 from Human Expanded Potential Stem Cells Counteracts Mesenchymal Stem Cell Senescence

2026-04-25

Abstract excerpt

<title>Abstract</title> <p>Background Human mesenchymal stem cells (hMSCs) remain the most clinically advanced adult stem cell source; however, their therapeutic potential is limited by rapid replicative senescence during ex vivo expansion. Replicative senescence in hMSCs is characterized by cell cycle arrest, acquisition of senescence-associated β-galactosidase (SA-β-Gal) activity, and secretion of the senescen...

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Literature Corpus work: 57250040-77fc-5664-bab4-51e3ba2a3253
DOI: 10.21203/rs.3.rs-8770632/v1

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