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Article

Secretome of Human Fetal Mesenchymal Stem Cell Ameliorates Replicative Senescence

19 Aug 2016

Abstract excerpt

Autologous mesenchymal stem cells (MSC) are widely used cell source for cell-based tissue repair and regeneration, but replicative senescence and the associated loss of cellular activity during in vitro expansion limit their therapeutic potential. How to preserve or even enhance the proliferation and differentiation ability of MSC from aged donors without genetic modification remains a challenge to meet clinical...

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PMID: 27539404
DOI: 10.1089/scd.2016.0079

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