Article

Comprehensive Bulk and Single-Cell RNA Sequencing Uncovers Senescence-Associated Biomarkers in Therapeutic Mesenchymal Stem Cells

2025-10-23

Abstract excerpt

<h4>Background</h4> Mesenchymal stem cells (MSCs) hold great promise in cell therapy, but their effectiveness declines with repeated cell divisions due to senescence. Canines, sharing aging characteristics with humans, serve as a valuable model to study this process in a translational context. <h4>Methods</h4> In the present study, we performed an in-depth characterization of senescence in canine MSCs using a co...

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Literature Corpus work: 21499308-340c-50e4-9f19-99ba2f41ccf6
DOI: 10.1101/2025.10.22.683610

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