Article

FN9-10ELP, an ECM-Mimetic Fusion Protein, Suppresses Etoposide-Induced Senescence in Human Mesenchymal Stem Cells

2025-07-31

Abstract excerpt

<h4>Background: </h4> Cellular senescence impairs the therapeutic potential of mesenchymal stem cells (MSCs), limiting their clinical applications. In this study, we aimed to eval-uate whether FN9-10ELP, a recombinant ECM-mimetic fusion protein composed of fi-bronectin type III domains 9 and 10 conjugated to elastin-like polypeptides, could sup-press senescence induced by the chemotherapeutic agent etoposide in hT...

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Literature Corpus work: 7163ca39-c300-5e67-8d72-1c70999f8623
DOI: 10.20944/preprints202507.2636.v1

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