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Article

Proteomics analysis of normal and senescent NG108-15 cells: GRP78 plays a negative role in cisplatin-induced senescence in the NG108-15 cell line.

PloS one - 1 Jan 2014

Li Wei, Wang Wei, Li Yan, Wang Wenwen, Wang Tian, Li Li, Han Zhiqiang, Wang Shixuan, Ma Ding, Wang Hui

Abstract excerpt

Accelerated senescence (ACS) leading to proliferative arrest is a physiological mechanism of the DNA damage response that occurs during tumor therapy. Our experiment was designed to detect unknown genes that may play important roles in cisplatin-induced senescence and to illustrate the related senescence mechanism. Using 2-dimension electrophoresis (2-DE), we identified 5 protein spots with different expression...

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Source

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Identifiers

PMID: 24621580
DOI: 10.1371/journal.pone.0090114
PMCID: PMC3951507

Genes

GSTM1
PPIA
VIM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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