Article

Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and CHIP

2023-07-13

Abstract excerpt

<h4>ABSTRACT</h4> Patients with JAK2V617F-positive myeloproliferative neoplasms (MPNs) and clonal hematopoiesis of indeterminate potential (CHIP) are at a significantly higher risk of cardiovascular diseases (CVDs). Endothelial cells (ECs) carrying the JAK2V617F mutation can be detected in many MPN patients. Here, we investigated the impact of endothelial JAK2V617F mutation on CVD development using both transgeni...

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Literature Corpus work: 31824798-e1e1-5b40-8986-0a99e2132ece
DOI: 10.1101/2023.07.12.548716

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