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VCP acts downstream of tTAFs to downregulate mono-ubiquitinated H2A and promote spermatocyte differentiation in <i>Drosophila</i>

2022-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Valosin-containing protein (VCP) binds and extracts ubiquitinated cargo to regulate protein homeostasis. While VCP has been studied primarily in aging and disease contexts, it also affects germline development. However, the precise molecular functions of VCP in the germline, particularly in males, are poorly understood. Using the Drosophila male germline as a model system, we find that VCP tran...

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Literature Corpus work
5711896e-4ac3-53f9-b51d-4385cd6fce81
DOI
10.1101/2022.12.21.521492
Open publication

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VCP acts downstream of tTAFs to downregulate mono-ubiquitinated H2A and promote spermatocyte differentiation in <i>Drosophila</i>DOI 10.1101/2022.12.21.521492
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