Article

Predicting efficacy of immunotherapy in mice with triple negative breast cancer using a cholesterol PET radiotracer

2023-10-03

Abstract excerpt

Predicting the response to cancer immunotherapy remains an unmet challenge in triple-negative breast cancer (TNBC) and other malignancies. T cells, the major target of current checkpoint inhibitor immunotherapies, accumulate cholesterol during activation to support proliferation and signaling. The requirement of cholesterol for anti-tumor functions of T cells led us to hypothesize that quantifying cellular accumul...

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Literature Corpus work: 56f15f94-9e08-543b-a077-afb66269ecca
DOI: 10.1101/2023.10.02.560577

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