Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer.

doi:10.1136/jitc-2020-002022

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Article

Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer.

Journal for immunotherapy of cancer - 1 Mar 2021

Cao Xu, Li Bolei, Chen Jing, Dang Jessica, Chen Siqi, Gunes E Gulsen, Xu Bo, Tian Lei, Muend Sabina, Raoof Mustafa, Querfeld Christiane, Yu Jianhua, Rosen Steven T, Wang Yingyu, Feng Mingye

Abstract excerpt

BACKGROUND: Limited therapeutic options are available for triple-negative breast cancer (TNBC), emphasizing an urgent need for more effective treatment approaches. The development of strategies by targeting tumor-associated macrophages (TAMs) to stimulate their ability of Programmed Cell Removal (PrCR) provides a promising new immunotherapy for TNBC treatment. METHODS: CD47 is a critical self-protective "don't...

Topics

Animals
Antineoplastic Agents, Immunological
Antineoplastic Combined Chemotherapy Protocols
CD47 Antigen
Cell Line, Tumor
Databases, Genetic
Drug Synergism
Female
Humans
Macrophage Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred BALB C

Mice, Knockout

NF-kappa B

Phagocytosis

Phenotype

RAW 264.7 Cells

Signal Transduction

Source

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Identifiers

PMID: 33753567
DOI: 10.1136/jitc-2020-002022
PMCID: PMC7986678

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