Article

NPC1 confers metabolic flexibility in Triple Negative Breast Cancer

2022-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Triple negative breast cancer (TNBC) often undergoes at least partial epithelial-to-mesenchymal transition (EMT) to facilitate metastasis. Identifying EMT-associated characteristics can reveal novel dependencies that may serve as therapeutic vulnerabilities in this aggressive breast cancer subtype. We find that NPC1 , which encodes the lysosomal cholesterol transporter Niemann-Pick Type C1 is h...

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Literature Corpus work: c3eb0fc7-2f26-5893-81b8-7d05abc19926
DOI: 10.1101/2022.05.05.490674

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