Article

Obesity Impairs the Antitumor Activity of CAR-T Cells in Triple-Negative Breast Cancer

2025-10-13

Abstract excerpt

<h4>Background</h4> We have reported that chimeric antigen receptor (CAR) T cells targeting B7-H3 (B7-H3.CAR) are effective in a preclinical model of triple negative breast cancer (TNBC), and have initiated a Phase I study to assess safety and efficacy. However, heterogeneous antigen expression and immunosuppressive tumor microenvironments (TME) remain roadblocks for effective CAR-T cell therapy. In particular, o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 511331a7-11bc-5698-8e7e-3802977ca8ed
DOI: 10.1101/2025.10.10.681694

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Obesity Impairs the Antitumor Activity of CAR-T Cells in Triple-Negative Breast CancerDOI 10.1101/2025.10.10.681694Read

Exploring the impact of body mass index on tumor biology and cancer developmentSemantic proximity Read

Metabolically activated macrophages in mammary adipose tissue link obesity to triple-negative breast cancerSemantic proximity Read

Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitorsSemantic proximity Read

PVT1 acts as a molecular scaffold to mediate PPARγ transcription and promote macrophage reprogramming in triple-negative breast cancerSemantic proximity Read

BET proteins in abnormal metabolism, inflammation, and the breast cancer microenvironmentSemantic proximity Read

To kill a cancer: Targeting the immune inhibitory checkpoint molecule, B7-H3Semantic proximity Read

Plasma Exosomes in Insulin Resistant Obesity Exacerbate Progression of Triple Negative Breast CancerSemantic proximity Read

Predicting efficacy of immunotherapy in mice with triple negative breast cancer using a cholesterol PET radiotracerSemantic proximity Read

Obesity-associated changes in molecular biology of primary breast cancerSemantic proximity Read

Obesity-mediated upregulation of the YAP/IL33 signaling axis promotes an immunosuppressive tumor microenvironment in breast cancerSemantic proximity Read

Obesity-associated changes in molecular biology of primary breast cancerSemantic proximity Read

Hyperglycemia enhances cancer immune evasion by inducing alternative macrophage polarization through increased O-GlcNAcylationSemantic proximity Read