Article

Global Pannexin 1-deletion increases tumor-infiltrating lymphocytes in the BRAF/Pten mouse melanoma model

2023-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Immunotherapies for malignant melanoma seek to boost the anti-tumoral response of CD8 + T cells but have a limited patient response rate, in part due to limited tumoral immune cell infiltration. Genetic or pharmacological inhibition of Pannexin 1 (PANX1) channel-forming protein is known to decrease melanoma cell tumorigenic properties in vitro and ex vivo . Here, we crossed Panx1 knockout (...

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Literature Corpus work: 56eceda9-6557-557f-9d1d-1ed46524727f
DOI: 10.1101/2023.07.28.551021

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