Article

A targetable PREX2/RAC1/PI3Kβ signalling axis confers resistance to clinically relevant therapeutic approaches in melanoma

2024-02-28

Abstract excerpt

Metastatic melanoma remains a major clinical challenge. Large-scale genomic sequencing of melanoma has identified bona fide activating mutations in RAC1 , with mutations of its upstream regulator, the RAC-GEF PREX2 , also commonly detected. Crucially, RAC1 mutations are associated with resistance to BRAF-targeting therapies. Despite the role of its homologue PREX1 in melanomagenesis, and evidence that some tru...

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Literature Corpus work: 9f8fc74a-2b2c-5ab3-a918-0ba9630bc876
DOI: 10.1101/2024.02.26.580534

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