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Article

Targeting BRAFV600E in an inducible murine model of melanoma.

The American journal of pathology - 1 Sept 2012

Hooijkaas Anna I, Gadiot Jules, van der Valk Martin, Mooi Wolter J, Blank Christian U

Abstract excerpt

The MAP kinase and PI3 kinase pathways have been identified as the most common pathways that mediate oncogenic transformation in melanoma, and the majority of compounds developed for melanoma treatment target one or the other of these pathways. In addition to such targeted therapies, immunotherapeutic approaches have shown promising results. A combination of these two treatment modalities could potentially result...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22796458
DOI: 10.1016/j.ajpath.2012.06.002

Genes

BRAF
PTEN

Variants

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