BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice.

doi:10.1158/1078-0432.CCR-12-1626

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Article

BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2013

Liu Chengwen, Peng Weiyi, Xu Chunyu, Lou Yanyan, Zhang Minying, Wargo Jennifer A, Chen Jie Qing, Li Haiyan S, Watowich Stephanie S, Yang Yan, Tompers Frederick Dennie, Cooper Zachary A, Mbofung Rina M, Whittington Mayra, Flaherty Keith T, Woodman Scott E, Davies Michael A, Radvanyi Laszlo G, Overwijk Willem W, Lizée Gregory, Hwu Patrick

Abstract excerpt

PURPOSE: Treatment of melanoma patients with selective BRAF inhibitors results in objective clinical responses in the majority of patients with BRAF-mutant tumors. However, resistance to these inhibitors develops within a few months. In this study, we test the hypothesis that BRAF inhibition in combination with adoptive T-cell transfer (ACT) will be more effective at inducing long-term clinical regressions of...

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PMID: 23204132
DOI: 10.1158/1078-0432.CCR-12-1626
PMCID: PMC4120472

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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