Article

Thermo-Dynamic Flux Balance Analysis, a novel approach to simulate circadian metabolism

2025-12-19

Abstract excerpt

Circadian metabolism arises from complex, time-dependent interactions across organs, yet experimental characterization in humans remains limited. Current whole-body metabolic models are either too large for dynamic simulation or insufficiently detailed to capture temporal physiology. We developed a multi-tissue human metabolic reconstruction, HGEM1 . 19+ , an extensively curated model for dynamic simulation. We...

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Literature Corpus work: 09cd0b44-5f6f-5ab5-ab5c-89c6f704a04d
DOI: 10.64898/2025.12.17.694837

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