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Stable transplantation of human mitochondrial DNA by high-throughput, pressurized isolated mitochondrial delivery

13 Jan 2021

Abstract excerpt

Generating mammalian cells with specific mitochondrial DNA (mtDNA)–nuclear DNA (nDNA) combinations is desirable but difficult to achieve and would be enabling for studies of mitochondrial-nuclear communication and coordination in controlling cell fates and functions. We developed ‘MitoPunch’, a pressure-driven mitochondrial transfer device, to deliver isolated mitochondria into numerous target mammalian cells...

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PMID: 33438576
DOI: 10.7554/elife.63102

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