Article

Generation of Human Regulatory Dendritic Cells from Cryopreserved Healthy Donor Cells and Hematopoietic Stem Cell Transplant Recipients

2023-08-14

Abstract excerpt

Acute graft versus host disease (GVHD) remains a significant complication following hematopoietic stem cell transplant (HSCT), despite improved human leukocyte antigen (HLA) matching and advances in prophylactic treatment regimens. Previous studies have shown promising results for future regulatory dendritic cell (DCreg) therapies in the amelioration of GVHD. This study evaluates the effects of cryopreservation on...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 56e26c7c-182e-5f8e-85fc-3360999ff442
DOI: 10.1101/2023.08.11.552986

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Generation of Human Regulatory Dendritic Cells from Cryopreserved Healthy Donor Cells and Hematopoietic Stem Cell Transplant RecipientsDOI 10.1101/2023.08.11.552986Read

Characterization of regulatory dendritic cells that mitigate acute graft-versus-host disease in older mice following allogeneic bone marrow transplantation.Semantic proximity Read

Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor AgonistsSemantic proximity Read

G-CSF mobilizes CD34 <sup>+</sup> regulatory monocytes that inhibit graft-versus-host diseaseSemantic proximity Read

Cord blood CD34+ cells cultured with FLT3L, stem cell factor, interleukin-6, and IL-3 produce CD11c+CD1a-/c- myeloid dendritic cells.Semantic proximity Read

Donor monocyte-derived macrophages promote human acute graft versus host diseaseSemantic proximity Read

Generation of mature dendritic cells with unique phenotype and function by in vitro short-term culture of human monocytes in the presence of interleukin-4 and interferon-beta.Semantic proximity Read

Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.Semantic proximity Read

Generation of dendritic cells from human bone marrow mononuclear cells: advantages for clinical application in comparison to peripheral blood monocyte derived cells.Semantic proximity Read

Effect of ex vivo culture duration on phenotype and cytokine production by mature dendritic cells derived from peripheral blood monocytes.Semantic proximity Read

Immature monocytes from G-CSF-mobilized peripheral blood stem cell collections carry surface-bound IL-10 and have the potential to modulate alloreactivity.Semantic proximity Read

A Pilot Study of Circulating Monocyte Subsets in Patients Treated with Stem Cell Transplantation for High-Risk Hematological Malignancies.Semantic proximity Read

Preparation of Induced Pluripotent Stem Cells Using Human Peripheral Blood MonocytesSemantic proximity Read