Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.

doi:10.4049/jimmunol.1401243

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Article

Human XCR1+ dendritic cells derived in vitro from CD34+ progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2014

Balan Sreekumar, Ollion Vincent, Colletti Nicholas, Chelbi Rabie, Montanana-Sanchis Frédéric, Liu Hong, Vu Manh Thien-Phong, Sanchez Cindy, Savoret Juliette, Perrot Ivan, Doffin Anne-Claire, Fossum Even, Bechlian Didier, Chabannon Christian, Bogen Bjarne, Asselin-Paturel Carine, Shaw Michael, Soos Timothy, Caux Christophe, Valladeau-Guilemond Jenny, Dalod Marc

Abstract excerpt

Human monocyte-derived dendritic cell (MoDC) have been used in the clinic with moderately encouraging results. Mouse XCR1(+) DC excel at cross-presentation, can be targeted in vivo to induce protective immunity, and share characteristics with XCR1(+) human DC. Assessment of the immunoactivation potential of XCR1(+) human DC is hindered by their paucity in vivo and by their lack of a well-defined in vitro...

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PMID: 25009205
DOI: 10.4049/jimmunol.1401243
PMCID: PMC4120898

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XCR1

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